Changes in hepatic tryptophan pyrrolase activity and plasma 11-hydroxycorticosteroid levels in rats after single and protracted alcohol administration and withdrawal

Single administration of ethanol in doses of 3 and 5 g/kg per os caused a 4--5fold increase in plasma 11-hydroxycorticosteroids after one hour and an approximately 2 fold increase in liver tryptophan pyrrolase activity after 5 hours. Adrenalectomy abolished the effect of ethanol. Prolonged alcoholiz...

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Bibliographic Details
Published inFarmakologiia i toksikologiia Vol. 44; no. 3; p. 319
Main Authors Kiseleva, I P, Lapin, I P, Prakh'e, I B, Samsonova, M L
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1981
Subjects
11-Hydroxycorticosteroids - blood
Adrenalectomy
Alcoholic Intoxication - metabolism
Alcoholism - metabolism
Animals
Dose-Response Relationship, Drug
Ethanol - administration & dosage
Humans
Liver - enzymology
Male
Motor Activity - drug effects
Rats
Substance Withdrawal Syndrome - metabolism
Tryptophan Oxygenase - metabolism
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Summary:Single administration of ethanol in doses of 3 and 5 g/kg per os caused a 4--5fold increase in plasma 11-hydroxycorticosteroids after one hour and an approximately 2 fold increase in liver tryptophan pyrrolase activity after 5 hours. Adrenalectomy abolished the effect of ethanol. Prolonged alcoholization of rats with 2--10% solutions of ethanol ad libitum resulted in the decreased tryptophan pyrrolase activity 2 months after the experiment was initiated. This effect seems likely to be accounted for by the inhibition of the synthesis of this enzyme and its activation by steroid hormones. Withdrawal of ethanol after 2-month alcoholization was associated with an appreciable potentiation of tryptophan pyrrolase activity.
ISSN:0014-8318