Effect of hypoxia on DNA synthesis and collagen levels in regenerating skin

During chronic hypoxia DNA synthesis in various areas of the regenerating skin decreased. Inhibition of epithelial and connective-tissue elements was accompanied by suppression of collagenogenesis, which finally led to longer-term wound healing.

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Bibliographic Details
Published inKosmicheskaia biologiia i aviakosmicheskaia meditsina Vol. 20; no. 3; p. 57
Main Authors Khomullo, G V, Lotova, V I, Cherniaev, A N, Vinogradov, I N
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1986
Subjects
Animals
Cell Division
Collagen - metabolism
DNA - biosynthesis
Epidermis - pathology
Epithelium - pathology
Granulation Tissue - metabolism
Granulation Tissue - pathology
Hypoxia - metabolism
Hypoxia - pathology
Male
Rats
Skin - metabolism
Time Factors
Wound Healing
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Summary:During chronic hypoxia DNA synthesis in various areas of the regenerating skin decreased. Inhibition of epithelial and connective-tissue elements was accompanied by suppression of collagenogenesis, which finally led to longer-term wound healing.
ISSN:0321-5040