Minute chromosomes in a case of chronic Ph1-positive myeloid leukemia

Minute chromosomes (mins) were found in all bone marrow cells in a 62-year-old woman with Ph1 positive chronic myeloid leukemia. The cells had a range of 39 to 50 chromosomes with a mode of 46. The examined metaphases had a variety of numerical and structural chromosome abnormalities, as well as 2 t...

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Bibliographic Details
Published inFolia haematologica (Leipzig, Germany : 1928) Vol. 110; no. 6; p. 942
Main Authors Suciu, S, Neamtu, S, Petrov, L, Marinca, E, Giurgiuman, M
Format Journal Article
LanguageGerman
Published Germany 1983
Subjects
Chromosome Aberrations
Chromosomes, Human, 21-22 and Y
Female
Humans
Leukemia, Myeloid - genetics
Middle Aged
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Summary:Minute chromosomes (mins) were found in all bone marrow cells in a 62-year-old woman with Ph1 positive chronic myeloid leukemia. The cells had a range of 39 to 50 chromosomes with a mode of 46. The examined metaphases had a variety of numerical and structural chromosome abnormalities, as well as 2 to 6 minute chromosomes. Our case supports the assumption that there may be a correlation between the presence of mins in leukemias and the resistance of the cells to chemotherapy or the rapid progression of the disease.
ISSN:0323-4347