The effect of the new amino acid-containing 1,4-dihydropyridine glutapyrone on penicillin-induced focal epileptic activity and convulsions induced by bicuculline and thiosemicarbazide

• Published in: Biulleten' eksperimental'noi biologii i meditsiny Vol. 116; no. 10; p. 357
• Main Authors: Karpova, M N, Germane, O K, Pankov, O Iu, Klusha, V E, Dubur, G Ia
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.10.1993
• Subjects: Animals; Anticonvulsants - therapeutic use; Bicuculline; Convulsants; Dihydropyridines - therapeutic use; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsies, Partial - chemically induced; Epilepsies, Partial - drug therapy; Glutamates - therapeutic use; Male; Mice; Mice, Inbred ICR; Penicillins; Rats; Rats, Wistar; Seizures - chemically induced; Seizures - drug therapy; Semicarbazides
• ISSN: 0365-9615

The experiments on focal penicillin-induced epileptic activity in the brain cortex (Wistar rats) and bicuculline- and thiosemicarbazide-induced seizures (Icr:Icl mice) showed that the glutapyrone possessed a significant antiepileptic activity. As previously shown, that glutapyrone has an influence on 45Ca2+ uptake by rat cortical synaptosomes (evoked by K+ depolarization) as compared with nifedipine and nimodipine, and it was effective in pentylenetetrazol-induced seizures in rats and mice. The mechanism of action of convulsants is associated with the disturbance of different links of GABAergic inhibition. It is suggested that the antiepileptic effects of glutapyrone are realized at least in part by the participation of GABAergic system.