The effect of the new amino acid-containing 1,4-dihydropyridine glutapyrone on penicillin-induced focal epileptic activity and convulsions induced by bicuculline and thiosemicarbazide

The experiments on focal penicillin-induced epileptic activity in the brain cortex (Wistar rats) and bicuculline- and thiosemicarbazide-induced seizures (Icr:Icl mice) showed that the glutapyrone possessed a significant antiepileptic activity. As previously shown, that glutapyrone has an influence o...

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Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 116; no. 10; p. 357
Main Authors Karpova, M N, Germane, O K, Pankov, O Iu, Klusha, V E, Dubur, G Ia
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.10.1993
Subjects
Animals
Anticonvulsants - therapeutic use
Bicuculline
Convulsants
Dihydropyridines - therapeutic use
Disease Models, Animal
Drug Evaluation, Preclinical
Epilepsies, Partial - chemically induced
Epilepsies, Partial - drug therapy
Glutamates - therapeutic use
Male
Mice
Mice, Inbred ICR
Penicillins
Rats
Rats, Wistar
Seizures - chemically induced
Seizures - drug therapy
Semicarbazides
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Summary:The experiments on focal penicillin-induced epileptic activity in the brain cortex (Wistar rats) and bicuculline- and thiosemicarbazide-induced seizures (Icr:Icl mice) showed that the glutapyrone possessed a significant antiepileptic activity. As previously shown, that glutapyrone has an influence on 45Ca2+ uptake by rat cortical synaptosomes (evoked by K+ depolarization) as compared with nifedipine and nimodipine, and it was effective in pentylenetetrazol-induced seizures in rats and mice. The mechanism of action of convulsants is associated with the disturbance of different links of GABAergic inhibition. It is suggested that the antiepileptic effects of glutapyrone are realized at least in part by the participation of GABAergic system.
ISSN:0365-9615