Changes in cerebral calcium, sodium and potassium after single or repeated administration of lithium in the rat

A single administration (IP) of lithium chloride in the rat induces a decrease in erythrocyte calcium, proportional to the lithium level (p less than 0.01) and a diminution in cerebral calcium (p less than 0.001) which is accompanied by decrease in cerebral sodium and potassium levels (p less than 0...

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Bibliographic Details
Published inEncéphale Vol. 11; no. 2; p. 53
Main Authors Scotto di Tella, A M, Pauli, A M, Dumoulin, B, Benzina, Z, Portugal, H, Pastor, J
Format Journal Article
LanguageFrench
Published France 01.03.1985
Subjects
Administration, Oral
Animals
Brain Chemistry - drug effects
Calcium - analysis
Erythrocytes - analysis
Female
Injections, Intraperitoneal
Lithium - analysis
Lithium - pharmacology
Potassium - analysis
Rats
Rats, Inbred Strains
Sodium - analysis
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Summary:A single administration (IP) of lithium chloride in the rat induces a decrease in erythrocyte calcium, proportional to the lithium level (p less than 0.01) and a diminution in cerebral calcium (p less than 0.001) which is accompanied by decrease in cerebral sodium and potassium levels (p less than 0.001). Repeated administration (IP + VO) has the same cerebral effects. The authors report that the reversible decrease in calcium, sodium and potassium, resulting from an increase in cerebral lithium levels, can be demonstrated on sampling at 1.30 and 3 hours (IP), or at 12 hours (VO). These results are relevant to the treatment of manic illnesses using calcium antagonists.
ISSN:0013-7006