Antigenic specificity of neuraminidase and structure of neuraminidase gene of influenza A(H1N1) serotype Hsw1N1 viruses isolated from man and animals

The enzyme immunoassay and neuraminidase activity inhibition test using polyclonal and monospecific antineuraminidase sera were employed to establish the similarities and differences in the antigenic structure of neuraminidase of influenza A viruses (H1N1), serovariant Hsw1N1, isolated from man in A...

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Bibliographic Details
Published inVoprosy virusologiĭ Vol. 34; no. 6; p. 656
Main Authors Chuvakova, Z K, Dem'ianenko, I V, Chaĭka, O V, Shilov, A A, Kim, E V, Rovnova, Z I, Isaeva, E I, Isaeva, E S
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1989
Subjects
Animals
Antigens, Viral - analysis
Epitopes - analysis
Genes, Viral
Hemagglutination Inhibition Tests
Humans
Influenza A virus - enzymology
Influenza A virus - genetics
Influenza A virus - immunology
Influenza A Virus, H1N1 Subtype
Neuraminidase - genetics
Neuraminidase - immunology
Species Specificity
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Summary:The enzyme immunoassay and neuraminidase activity inhibition test using polyclonal and monospecific antineuraminidase sera were employed to establish the similarities and differences in the antigenic structure of neuraminidase of influenza A viruses (H1N1), serovariant Hsw1N1, isolated from man in Alma-Ata (USSR), 1984, New Jersey (USA), 1976, and Pazardjik (BPR), 1982, as well as from swine and birds. Oligonucleotide mapping revealed significant structural differences in the genes coding for neuraminidase of Hsw1N1 viruses. The experimental results indicate a high degree of the enzyme variability in this group of viruses.
ISSN:0507-4088