Increase of the functional activity of natural killers under the effects of the pharmacological correction of the sympathoadrenal system state in patients with lung cancer

The influence of drugs improving sympathoadrenal system status on natural killer (NK) functional activity was studied in lung cancer patients. The activity of adenosine-metabolizing enzymes (adenosine deaminase and 5'-nucleotidase) in NK cells was found significantly altered, suggesting the inv...

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Bibliographic Details
Published inVoprosy onkologij Vol. 36; no. 1; p. 13
Main Authors Umanskiĭ, V Iu, Balitskaia, E K, Shmal'ko, Iu P, Kas'ianenko, I V
Format Journal Article
LanguageRussian
Published Russia (Federation) 1990
Subjects
5'-Nucleotidase - metabolism
Adenosine Deaminase - metabolism
Adrenal Glands - drug effects
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Humans
Killer Cells, Natural - enzymology
Killer Cells, Natural - immunology
Lung Neoplasms - drug therapy
Lung Neoplasms - immunology
Middle Aged
Oxprenolol - pharmacology
Stimulation, Chemical
Sympathetic Nervous System - drug effects
Vitamin U - pharmacology
Vitamins - pharmacology
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Summary:The influence of drugs improving sympathoadrenal system status on natural killer (NK) functional activity was studied in lung cancer patients. The activity of adenosine-metabolizing enzymes (adenosine deaminase and 5'-nucleotidase) in NK cells was found significantly altered, suggesting the involvement of this phenomenon in decreasing NK activity under tumor growth. Pharmacological correction of sympathoadrenal system status was followed by an increase in NK functional activity in lung cancer patients.
ISSN:0507-3758