Updating of relative data on tocopherols in clinical biochemistry

The working group on lipophilic vitamins of the FSBC has reviewed current knowledge in the field of tocopherols and tried to summarize the most important and recent aspects that may be useful to clinical practitioners. The molecular structure of tocopherols and tocotrienols, their biogenesis, their...

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Published inAnnales de biologie clinique (Paris) Vol. 52; no. 1; p. 9
Main Authors Artur, Y, Cals, M J, Clerc, M, Covi, G, Crastes de Paulet, A, Cruz-Pastor, M, Herbeth, B, Laschi-Loquerie, A, Leclercq, M, Mazière, J C
Format Journal Article
LanguageFrench
Published France 1994
Subjects
Arteriosclerosis - metabolism
Cell Membrane - physiology
Female
Humans
Intestinal Absorption - physiology
Liver - metabolism
Male
Neoplasms - metabolism
Renal Insufficiency - metabolism
Vitamin E - chemistry
Vitamin E - metabolism
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Summary:The working group on lipophilic vitamins of the FSBC has reviewed current knowledge in the field of tocopherols and tried to summarize the most important and recent aspects that may be useful to clinical practitioners. The molecular structure of tocopherols and tocotrienols, their biogenesis, their analysis in foods, their metabolism in humans, their measurement in biological fluids, and the organism's needs and dietary requirements are reviewed. Their main functions as antioxidants and free radical scavengers are described at the molecular, ultra-structural, cellular and organ levels. The interest of these vitamins in three pathologies in which oxidative-stress has been implicated (atherosclerosis, cancer, kidney failure) is discussed.
ISSN:0003-3898