Effect of glutamate on the trace element content in the mitochondria of the liver, heart and kidneys of rats with acute and chronic hypoxia

• Published in: Ukrains'kyi biokhimichnyi zhurnal Vol. 48; no. 5; p. 559
• Main Authors: Glotov, N A, Vul'fson, A M
• Format: Journal Article
• Language: Russian
• Published: Ukraine 01.09.1976
• Subjects: Acute Disease; Animals; Chronic Disease; Copper - metabolism; Glutamates - pharmacology; Hypoxia - metabolism; Kidney - metabolism; Magnesium - metabolism; Male; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondria, Liver - drug effects; Mitochondria, Muscle - drug effects; Myocardium - metabolism; Rats; Trace Elements - metabolism; Zinc - metabolism
• ISSN: 0041-610X

Acute hypoxia ("height" 8000 metres, 60 minutes) decreases concentration of copper, zinc and magnesium in mitochondria of the liver, kidney, that of copper and magnesium decreases in the heart. Chronic hypoxia ("height" 6000 metres, 6 hours a day for 2 weeks) also causes a decrease in the concentration of copper, zinc and magnesium in mitochondria of the liver, kidney and that of copper and magnesium--in the heart. Glutamic acid (acute and chronic hypoxia) increases the level of copper, zinc and magnesium in mitochondria of the liver, heart and kidney of albino rats which is close to its values in the normal animals.