Reversibility of severe digitoxin poisoning with antidigoxin antibodies

We report a case of severe digitoxin poisoning treated at the stage of ventricular fibrillation by infusion of FAB antidigoxin fragments with low in vitro covering properties. There were no side effects. The possibility of rapidly reversing the prognosis will permit the use of specific FAB fragments...

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Bibliographic Details
Published inAnnales de médecine interne Vol. 134; no. 6; p. 555
Main Authors Domart, Y, Bismuth, C, Pontal, P G, Scherrmann, J M, Baud, F, Muszynski, J, Elkhouly, M, Fournier, P E
Format Journal Article
LanguageFrench
Published France 1983
Subjects
Aged
Digitoxin - blood
Digitoxin - poisoning
Digoxin - immunology
Electrocardiography
Humans
Immunoglobulin Fab Fragments
Male
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Summary:We report a case of severe digitoxin poisoning treated at the stage of ventricular fibrillation by infusion of FAB antidigoxin fragments with low in vitro covering properties. There were no side effects. The possibility of rapidly reversing the prognosis will permit the use of specific FAB fragments before the onset of potentially lethal cardiac arrhythmias, when these antibodies become more generally available.
ISSN:0003-410X