Computed analysis of brain electrograms under the action of psychotropic drugs

The computed analysis of the EEG-effects of a neuroleptic ethaperazine and an antidepressant melipramine administered in different doses was made in the experiments on cats. It was established that ethaperazine (3 mg/kg) and melipramine (6 mg/kg) increase the spectral power in the range of 1-2 Hz; t...

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Bibliographic Details
Published inFarmakologiia i toksikologiia Vol. 52; no. 3; p. 18
Main Authors Omel'chenko, V P, Matua, S P, Grishin, A D
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1989
Subjects
Animals
Brain - drug effects
Cats
Electroencephalography
Image Processing, Computer-Assisted
Imipramine - pharmacology
Perphenazine - pharmacology
Psychotropic Drugs - pharmacology
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Summary:The computed analysis of the EEG-effects of a neuroleptic ethaperazine and an antidepressant melipramine administered in different doses was made in the experiments on cats. It was established that ethaperazine (3 mg/kg) and melipramine (6 mg/kg) increase the spectral power in the range of 1-2 Hz; the maximal effect was noted 2 hours after their oral administration Ethaperazine primarily decreases the powers of the spectra of the hypothalamus and reticulotegmental nucleus in the range of 13-14 Hz and over. Melipramine in a dose of 6 mg/kg decreases the spectral power of the hippocampus in the range of 4-12 Hz, of the mediodosal and caudal nuclei in the range of 8-12 Hz. The peak of the effects of melipramine administered in a dose of 12 mg/kg manifests itself in the decrease of the power in the range of 14-20 Hz and over both of the cortical and subcortical structures of EEG spectra.
ISSN:0014-8318