Effect of acid metabolites on the osteoinductive activity of the bone matrix

The osteoinductive activity of bone matrix demineralized in acid metabolites of glycolysis and Krebs cycle have been studied in rats. The highest osteoinductive effect was reached during the demineralization in oxaloacetic acid, the lowest one--in the malic acid. The regulatory role of glycolysis me...

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Bibliographic Details
Published inNauchnye doklady vysshei shkoly. Biologicheskie nauki no. 5; p. 20
Main Authors Sumarokov, D D, Shamsudinov, A Kh, Shvyrkov, M B, Siziakov, S L
Format Journal Article
LanguageRussian
Published Russia (Federation) 1987
Subjects
Animals
Bone and Bones - metabolism
Bone Matrix - metabolism
Bone Matrix - physiology
Bone Transplantation
Citric Acid Cycle
Glycolysis
Male
Minerals - metabolism
Osteogenesis
Rats
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Summary:The osteoinductive activity of bone matrix demineralized in acid metabolites of glycolysis and Krebs cycle have been studied in rats. The highest osteoinductive effect was reached during the demineralization in oxaloacetic acid, the lowest one--in the malic acid. The regulatory role of glycolysis metabolites and Krebs Cycle in posttraumatic osteogenesis is under discussion.
ISSN:0470-4606