Detection of rhinoliquorrhea with 99mTc-labelled human serum albumin

99mTc-labelled human serum albumin was used in 42 patients, 35 without and 7 with proven rhinoliquorrhoea, to combine liquor scintigraphy with the detection of liquor fistula. Since some 99mTc is split off from albumin during the time of investigation and is actively secreted by mucous membranes and...

Full description

Saved in:
Bibliographic Details
Published inNuclear medicine Vol. 22; no. 2; p. 106
Main Authors Schicha, H, Schürnbrand, P, Schaake, T, Emrich, D
Format Journal Article
LanguageGerman
Published Germany 01.04.1983
Subjects
Adolescent
Adult
Aged
Cerebrospinal Fluid Rhinorrhea - diagnostic imaging
Female
Humans
Male
Middle Aged
Radionuclide Imaging
Serum Albumin
Technetium
Technetium Tc 99m Aggregated Albumin
Online AccessGet more information

Cover

More Information
Summary:99mTc-labelled human serum albumin was used in 42 patients, 35 without and 7 with proven rhinoliquorrhoea, to combine liquor scintigraphy with the detection of liquor fistula. Since some 99mTc is split off from albumin during the time of investigation and is actively secreted by mucous membranes and salivary glands it was not possible to detect liquorrhoea by calculation of activity ratios like that of secretion of the nose to blood or saliva. But dividing the activity in the secretion of the nose by that in saliva after 2 and 6 hrs this ratio was independent of the amount of activity and had a sensitivity of 100% and a specificity of 93% in detecting a liquor fistula. Combining scintigrams of the subarachnoidal space with the search for liquorrhoea using an always available radiopharmaceutical such as labelled HSA might be attractive. In 4 of 7 patients with a liquor fistula there was additionally a pathologic result obtained with scintigraphy of the subdural space.
ISSN:0029-5566