Comparative clinical efficacy of cephotaxim and cefuroxime against the pathogens of inflammation in obstetrics and gynecology

• Published in: Antibiotiki Vol. 28; no. 6; p. 456
• Main Authors: Voropaeva, S D, Emel'ianova, A I, Ankirskaia, A S, Saakian, S S, Maĭorova, V N
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.06.1983
• Subjects: Bacterial Infections - drug therapy; Cefotaxime - therapeutic use; Cefuroxime - metabolism; Cefuroxime - therapeutic use; Cephalosporins - metabolism; Cephalosporins - therapeutic use; Endometritis - drug therapy; Enterococcus faecalis - drug effects; Escherichia coli - drug effects; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases - drug therapy; Kinetics; Klebsiella - drug effects; Pregnancy; Pseudomonas aeruginosa - drug effects; Puerperal Infection - drug therapy; Pyelonephritis - drug therapy; Staphylococcus aureus - drug effects
• ISSN: 0003-5637

The use of cephotaxim in the treatment of obstetric and gynecological patients with various infectious complications, as well as in the treatment of newborn infants in the Department of Intensive Therapy showed it to be highly effective in 100 per cent of the cases. The adverse reactions of cephotaxim were observed in 1 out of 43 patients. It should be noted that cephotaxim did not inhibit the host anaerobic indigenous flora. No cases of dysbacteriosis were recorded. Comparative analysis of the data on determination of the MIC of cephotaxim and cephuroxim with respect to various species of opportunistic microorganisms demonstrated that cephuroxim was more active against Staph. aureus, while cephotaxim against Klebsiella. Cephotaxim displayed activity against part of the strains of Ps. aeruginosa and streptococci of group D, which was not common to cephalosporins of the previous generations.