Changes in fibronectin biosynthesis in human embryonal fibroblasts with trisomy for chromosomes 7 and 9

Biosynthesis of fibronectin in 2 strains of aneuploid human fibroblasts with trisomy by chromosomes 7 and 9 was about 2-fold decreased as compared with normal diploid fibroblasts. The most distinct decrease of the fibronectin biosynthesis was observed at the logarithmic phase of the cell culture gro...

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Bibliographic Details
Published inVoprosy meditsinskoi khimii Vol. 31; no. 1; p. 125
Main Authors Belkin, V M, Kukharenko, V I, Volodarskaia, S M, Grinberg, K N, Mazurov, V I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.1985
Subjects
Cell Line
Chromosomes, Human, 6-12 and X
Diploidy
Embryo, Mammalian
Fibroblasts - cytology
Fibroblasts - metabolism
Fibronectins - biosynthesis
Humans
Proline - metabolism
Trisomy
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Summary:Biosynthesis of fibronectin in 2 strains of aneuploid human fibroblasts with trisomy by chromosomes 7 and 9 was about 2-fold decreased as compared with normal diploid fibroblasts. The most distinct decrease of the fibronectin biosynthesis was observed at the logarithmic phase of the cell culture growth. The cells with anomalous karyotype exhibited also the decreased rate of secretion of the impulse labelled fibronectin. The decrease in the rate of fibronectin and collagen production (main proteins of intercellular substance) in fibroblasts with the chromosomes anomalies might be responsible for irreversible impairments of the embryo development, resulting in spontaneous abortion.
ISSN:0042-8809