Contribution of animal experiments in the problem of a long-term indomethacin therapy in advanced nephron loss

Residual nephrons are subject to compensatory adaptation at which the glomerular hyperfiltration and convection of macromolecules (proteins) are of pathogenic character in the progression of nephropathy. The influence of indomethacin at dosages of 2 or 3 mg/kg body weight/day was investigated in lon...

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Bibliographic Details
Published inZeitschrift fur Urologie und Nephrologie Vol. 81; no. 12; p. 725
Main Authors Hortian, B, Wüstenberg, P W, Klinkmann, H, Schröder, J, Schumann, L
Format Journal Article
LanguageGerman
Published Germany 01.12.1988
Subjects
Animals
Female
Glomerular Filtration Rate
Indomethacin - administration & dosage
Indomethacin - pharmacology
Kidney - drug effects
Kidney Diseases - complications
Mice
Nephrectomy
Nephrons - drug effects
Rats
Rats, Inbred Strains
Time Factors
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Summary:Residual nephrons are subject to compensatory adaptation at which the glomerular hyperfiltration and convection of macromolecules (proteins) are of pathogenic character in the progression of nephropathy. The influence of indomethacin at dosages of 2 or 3 mg/kg body weight/day was investigated in long-term feeding trials (8 months) on inbred female Wistar rats after unilateral nephrectomy and additional resection of both kidney poles. The results show a significant deterioration of vital prognosis under indomethacin medication independently of the dosage.
ISSN:0044-3611