Serological property of perchloric acid-soluble glycoprotein fractions of human meconium

Perchloric acid-soluble fractions (PASFs) were separated, in yields of 87.0-151.9 mg per 1.0 g of wet meconium sample, from six samples of human meconium, and identified as glycoproteins having 41.2-74.1% carbohydrate by chemical composition analysis. Six PASFs reacted with anti-A, -B, -Lea and -Leb...

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Published inYakugaku zasshi Vol. 113; no. 7; pp. 532 - 536
Main Authors Uchide, N, Ohyama, K, Yamakawa, T, Watanabe, H, Hirakawa, S, Yoneyama, K, Ohkuma, S
Format Journal Article
LanguageJapanese
Published Japan 01.07.1993
Subjects
Amino Acids - analysis
Glycoproteins - analysis
Glycoproteins - isolation & purification
Hemagglutination Inhibition Tests
Humans
Infant, Newborn
Lectins
Meconium - chemistry
Perchlorates
Plant Lectins
Solubility
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Summary:Perchloric acid-soluble fractions (PASFs) were separated, in yields of 87.0-151.9 mg per 1.0 g of wet meconium sample, from six samples of human meconium, and identified as glycoproteins having 41.2-74.1% carbohydrate by chemical composition analysis. Six PASFs reacted with anti-A, -B, -Lea and -Leb sera, but did not react with anti-M and -N sera. These PASFs alos reacted with many lectins such as DBA, UEA-I, Vicia graminea lectin (VGA), Vicia unijuga lectin (VUA), Con A, WGA, RCA-I, PHA-E, SBA, SJA, and influenza A and B viruses. The serological results show that six PASFs contained VGA or VUA-binding (Vgu) glycoproteins as new oncofetal substances, but did not contain M and N blood group substances.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0031-6903