Dynamics of energy requirements, detoxication and biosynthesis of hepatocyte macromolecules in acute radiation injury

The functional state of the mitochondrial electron transport chain and of hydroxylation system of endoplasmic reticulum and biosynthesis of macromolecules in hepatocytes were studied during acute radiation decrease induced by whole-body gamma-irradiation of mice with doses of 6 and 8 Gy. An increase...

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Published inRadiobiologiia Vol. 25; no. 4; p. 462
Main Authors Sharygin, V L, Avakian, M A, Pulatova, M K, Efremova, O I, Mitrokhin, Iu I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.1985
Subjects
Animals
Cobalt Radioisotopes
DNA - biosynthesis
Energy Metabolism
Gamma Rays
Liver - metabolism
Liver - radiation effects
Male
Mice
Protein Biosynthesis
Radiation Injuries, Experimental - metabolism
RNA - biosynthesis
Whole-Body Irradiation
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Summary:The functional state of the mitochondrial electron transport chain and of hydroxylation system of endoplasmic reticulum and biosynthesis of macromolecules in hepatocytes were studied during acute radiation decrease induced by whole-body gamma-irradiation of mice with doses of 6 and 8 Gy. An increase in the degree of reduction of the mitochondrial electron transport chain at early post-irradiation time (up to 2 h) was demonstrated by the ESR method. At the same time stimulation of transcription and marked inhibition of rates of protein and DNA biosyntheses were noted. There was an increase in the content of flavosemiquinone radicals, iron-sulfur centers, cytochrome P-450, and Mn2+- and Mo5+-containing centers, and an increases in rate of biosynthesis of proteins, RNA and DNA on 2-3 days in post-radiation period. A further development of radiation decrease (days 4-8) was characterised by a decrease in the intensity of ESR signals of all the paramagnetic centers under study.
ISSN:0033-8192