pS2 protein and breast cancer

pS2 is a small protein (7000 daltons) that is prevalently expressed in human breast cancer positive for estrogen receptors: protein is, in fact, induced by estrogen stimulation. Studies indicate that pS2 protein is a marker for hormone-dependent breast tumors and that its expression is helpful in th...

Full description

Saved in:
Bibliographic Details
Published inMinerva ginecologica Vol. 47; no. 12; p. 553
Main Authors Torre, E A, Fulco, R A
Format Journal Article
LanguageItalian
Published Italy 01.12.1995
Subjects
Biomarkers, Tumor - analysis
Breast Neoplasms - metabolism
Female
Humans
Immunohistochemistry
Neoplasm Proteins - analysis
Neoplasm Proteins - physiology
Neoplasms, Hormone-Dependent
Prognosis
Proteins
Radioimmunoassay
Receptors, Estradiol - analysis
Receptors, Estradiol - metabolism
Receptors, Estrogen - analysis
Trefoil Factor-1
Tumor Suppressor Proteins
Online AccessGet more information

Cover

More Information
Summary:pS2 is a small protein (7000 daltons) that is prevalently expressed in human breast cancer positive for estrogen receptors: protein is, in fact, induced by estrogen stimulation. Studies indicate that pS2 protein is a marker for hormone-dependent breast tumors and that its expression is helpful in the prognosis. The presence of pS2, in fact, besides being associated in 96% of the cases to the positivities for estrogen receptors, is associated with longer overall, and disease free, survival. The pS2 protein is also expressed in normal stomach mucosa; its physiological function is unknown.
ISSN:0026-4784