Polyneuropathy associated with osteosclerotic myeloma. Excellent response to chemotherapy

We report a 36-year-old patient with progressive tetraparesis and diffuse osteosclerotic lesions without secretion of a monoclonal component, in whom a diagnosis of non-secreting diffuse osteosclerotic myeloma with POEMS syndrome was made with open rib biopsy. We discuss the clinical, biological, ra...

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Bibliographic Details
Published inNeurología (Barcelona, Spain) Vol. 5; no. 3; p. 102
Main Authors Antela López, A, Requena Caballero, I, Masa Vázquez, L, Antela Carrera, C, Barrio Gómez, E
Format Journal Article
LanguageSpanish
Published Spain 01.03.1990
Subjects
Adult
Cyclophosphamide - therapeutic use
Drug Therapy, Combination
Humans
Male
Multiple Myeloma - complications
Multiple Myeloma - drug therapy
Nervous System Diseases - etiology
Osteosclerosis - complications
Prednisone - therapeutic use
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Summary:We report a 36-year-old patient with progressive tetraparesis and diffuse osteosclerotic lesions without secretion of a monoclonal component, in whom a diagnosis of non-secreting diffuse osteosclerotic myeloma with POEMS syndrome was made with open rib biopsy. We discuss the clinical, biological, radiological and electrophysiological features of this patient. We analyze the possible pathogenesis of his neurological involvement, with a detailed review of the relevant literature. Finally, we underline the therapeutic success with a combination of cyclophosphamide and prednisone, comparing it with the previous references to this therapeutic modality, and emphasize the validity of our therapeutic approach.
ISSN:0213-4853