Effects of carbontetrachloride and chenodeoxycholic acid on hepatic monooxygenase system, lipid peroxidation and some immunologic parameters in rats

• Published in: Acta physiologica et pharmacologica Bulgarica Vol. 22; no. 2; p. 45
• Main Authors: Alexeyeva, I N, Berezovsky, V A, Bryzgina, T M, Pavlovich, S I, Alexyuk, L I, Makogon, N V, Gotsulyak YaN, Martinova, T V
• Format: Journal Article
• Language: English
• Published: Bulgaria 1996
• Subjects: Animals; Antigen-Antibody Complex - blood; Carbon Tetrachloride - pharmacology; Chenodeoxycholic Acid - pharmacology; Cholagogues and Choleretics - pharmacology; Cytochrome P-450 Enzyme System - metabolism; Female; Lipid Peroxidation; Liver - drug effects; Liver - metabolism; Lymphocyte Activation - drug effects; Rats; Rats, Wistar
• ISSN: 0323-9950

The effect of chenodeoxycholic acid on liver monooxygenase system, lipid peroxidation, lymphocyte proliferation, and immune complexes formation was studied in carbontetrachloride-treated rats. Chenodeoxycholic acid increased the content of both cytochrome P-450 and cytochrome b5 and the rate of aminopyrine N-demethylation in liver microsomal fractions. It also normalized lipid peroxidation in the liver and the proliferative activity of blood lymphocytes activated by phytohemagglutinin. Soon after injection chenodeoxycholic acid caused disturbances of the liver histostructure and of the microcirculation followed by regenerative processes. Liver histostructure tended to return to normal. The level of serum immune complexes was increased. The relationship between the changes in monooxygenase system, lipid peroxidation and immunologic parameters is discussed.