Enzymes are the allergenic components of inhaled pancreatin

Pancreatic extracts had caused respiratory disease in five patients. Four of them were not atopic. In four cases alpha-amylase and in two cases trypsin could be identified as causative allergen using RAST and RAST-inhibition. In addition, demonstration of immunologic cross-reactivity between porcine...

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Bibliographic Details
Published inDeutsche medizinische Wochenschrift Vol. 109; no. 7; p. 257
Main Authors Baur, X, Wiessmann, K J, Wüthrich, B
Format Journal Article
LanguageGerman
Published Germany 17.02.1984
Subjects
Adult
Allergens - analysis
alpha-Amylases - immunology
Bronchial Provocation Tests
Drug Industry
Female
Humans
Immunoglobulin E - analysis
Male
Middle Aged
Occupational Diseases - chemically induced
Pancreatin - adverse effects
Pancreatin - immunology
Radioallergosorbent Test
Respiratory Hypersensitivity - chemically induced
Trypsin - immunology
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Summary:Pancreatic extracts had caused respiratory disease in five patients. Four of them were not atopic. In four cases alpha-amylase and in two cases trypsin could be identified as causative allergen using RAST and RAST-inhibition. In addition, demonstration of immunologic cross-reactivity between porcine and bovine pancreatin was possible. This most likely can be attributed to the structurally closely related enzymes alpha-amylase and trypsin occurring in both animal species.
ISSN:0012-0472