The effect of hydrocortisone on the activity of 5'-nucleotidase and adenosine deaminase in the hypothalamus and hippocampus of the rat brain

The effect of single (1.4 and 24 h) and long-term (7 days) hydrocortisone intramuscular administration (5 mg/100 g of body mass) on 5'-nucleotidase and adenosine deaminase activities in homogenate and subcellular fractions of the rat brain hypothalamus and hippocampus has been studied. Enzymati...

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Bibliographic Details
Published inProblemy ėndokrinologii Vol. 36; no. 3; p. 49
Main Authors Kononenko, V Ia, Kosmina, N M, Pil'kevich, L I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1990
Subjects
5'-Nucleotidase - metabolism
Adenosine Deaminase - metabolism
Animals
Hippocampus - drug effects
Hippocampus - enzymology
Hydrocortisone - pharmacology
Hypothalamus - drug effects
Hypothalamus - enzymology
Male
Nucleoside Deaminases - metabolism
Rats
Rats, Inbred Strains
Synaptosomes - drug effects
Synaptosomes - enzymology
Time Factors
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Summary:The effect of single (1.4 and 24 h) and long-term (7 days) hydrocortisone intramuscular administration (5 mg/100 g of body mass) on 5'-nucleotidase and adenosine deaminase activities in homogenate and subcellular fractions of the rat brain hypothalamus and hippocampus has been studied. Enzymatic activity of adenosine metabolism in hypothalamus and hippocampus has been shown to undergo changes with the duration of hydrocortisone administration. A possible role of adenosine in the mechanism of glucocorticoid action in the CNS and the regulation of the hypothalamic-pituitary-adrenal axis is under discussion.
ISSN:0375-9660