Changes in the primary structure of rabbit muscle aldolase under the influence of valine against a background of prolonged fasting

The primary structure of the muscle aldolase molecule was studied as affected by semilethal doses of valine administered the abdominal cavity of the rabbits after a long fasting. It is established that in spite of differences in the amino acid composition of the protein, uniformity of the peptides d...

Full description

Saved in:
Bibliographic Details
Published inUkrains'kyi biokhimichnyi zhurnal Vol. 48; no. 5; p. 620
Main Authors Gulyĭ, M F, Orlovskaia, N N, Gogolinskaia, G K, Veselovskaia, L D, Solodova, E V
Format Journal Article
LanguageUkrainian
Published Ukraine 01.09.1976
Subjects
Amino Acid Sequence
Animals
Dose-Response Relationship, Drug
Fasting
Fructose-Bisphosphate Aldolase - analysis
Fructose-Bisphosphate Aldolase - metabolism
Molecular Conformation
Muscles - enzymology
Peptide Chain Termination, Translational - drug effects
Peptide Fragments - pharmacology
Rabbits
Structure-Activity Relationship
Time Factors
Valine - pharmacology
Online AccessGet more information

Cover

More Information
Summary:The primary structure of the muscle aldolase molecule was studied as affected by semilethal doses of valine administered the abdominal cavity of the rabbits after a long fasting. It is established that in spite of differences in the amino acid composition of the protein, uniformity of the peptides distribution in the process of bromo-cyanogen fragments elution and the total amount of amino acid residues in the identical fragments are maintained. Changes are found only in the point-replacements by amino acids in C-fragment of the molecule (asparagine is replaced by valine and threonine by serine).
ISSN:0041-610X