Use of cytostatics in polymer-drug complexes in the treatment of malignant neoplasms of the maxilla

The authors analyze the efficacy of antitumor drugs deposited with cyanoacrylate adhesive solution in therapy of Stages III-IV maxillary tumors. Immediate and late results of therapy with these compositions of 21 patients evidence that such treatment is not associated with the wound or general toxic...

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Bibliographic Details
Published inSovetskaia meditsina no. 1; p. 23
Main Authors Rusakov, I G, Ol'shanskiĭ, V O, Savizhkov, A M, Kislichko, A G, Akimova, A Ia
Format Journal Article
LanguageRussian
Published Russia (Federation) 1990
Subjects
Adult
Aged
Animals
Bleomycin - administration & dosage
Carubicin - administration & dosage
Clinical Trials as Topic
Cyanoacrylates - administration & dosage
Daunorubicin - analogs & derivatives
Drug Evaluation, Preclinical
Drug Implants
Female
Humans
Male
Maxilla - drug effects
Maxilla - surgery
Maxillary Neoplasms - surgery
Middle Aged
Postoperative Care
Rats
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Summary:The authors analyze the efficacy of antitumor drugs deposited with cyanoacrylate adhesive solution in therapy of Stages III-IV maxillary tumors. Immediate and late results of therapy with these compositions of 21 patients evidence that such treatment is not associated with the wound or general toxic complications and that wounds may be managed without tampons. Deposition of the drug and its regulated elimination from the composition helps create a high concentration of the agent at the operation site where the tumor elements remained after surgery; this permits expecting better late results.
ISSN:0038-5077