Role pf genetic and other biomarkers in the prognostication of postoperative course in patients with lung cancer

Relationships between genetic polymorphisms (ABO, RH, HP, TF, GC, Pi, ACP1, PGM1, GLO1, PTC) and some clinical, biochemical, and functional parameters were studied in patients with epidermoid carcinoma of the lung who were divided into 2 groups: those with uncomplicated and complicated postoperative...

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Published inVestnik Rossiĭskoĭ akademii medits︠i︡nskih nauk no. 12; p. 3
Main Authors Tsybikova, E B, Spitsyn, V A, Agapova, R K, Chizhov, A I, Perel'man, M I, Bochkov, N P
Format Journal Article
LanguageRussian
Published Russia (Federation) 1996
Subjects
Adult
Aged
Biomarkers, Tumor
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - surgery
Genetic Markers
Humans
Lung Neoplasms - diagnosis
Lung Neoplasms - genetics
Lung Neoplasms - surgery
Male
Middle Aged
Postoperative Complications
Prognosis
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Summary:Relationships between genetic polymorphisms (ABO, RH, HP, TF, GC, Pi, ACP1, PGM1, GLO1, PTC) and some clinical, biochemical, and functional parameters were studied in patients with epidermoid carcinoma of the lung who were divided into 2 groups: those with uncomplicated and complicated postoperative courses of the disease. They were found to be different in the two groups. The values of ESR, albumin, lymphocytes, vital capacity, and RQ are the most distinctive signs that differentiate the patient groups. A high correlation was found between the signs in patients with an uncomplicated postoperative course. A less correlation between the signs, as a higher intergroup variability in the majority of the signs under study suggests that there is a significantly impaired physiological homeostasis in the group of patients with a complicated course. Comparing the mean values and dispersions shows their equal direction in the two groups of patients irrespective of their genetic polymorphism. The GC system is associated with profound changes of the studied signs in the group of patients with an uncomplicated course and GC*1F carriage should be regarded as a poor factor in the prognosis of the disease.
ISSN:0869-6047