Appearance of circulating immune complexes in patients with Hodgkin's disease and the etiology of this disease

The serum of 47 previously untreated patients with Hodgkin disease (HD) was subjected to analysis for the presence and level of circulating immune complexes (IC) detected by the tests of inhibition of EA and EAC rosette formation. The control group included 100 healthy persons, health service worker...

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Bibliographic Details
Published inWiadomości lekarskie (1960) Vol. 45; no. 19-20; p. 740
Main Authors Dziewulska-Bokiniec, A, Sztaba-Kania, M
Format Journal Article
LanguagePolish
Published Poland 01.10.1992
Subjects
Adolescent
Adult
Aged
Antigen-Antibody Complex - analysis
Female
Hodgkin Disease - immunology
Humans
Male
Middle Aged
Reference Values
Rosette Formation
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Summary:The serum of 47 previously untreated patients with Hodgkin disease (HD) was subjected to analysis for the presence and level of circulating immune complexes (IC) detected by the tests of inhibition of EA and EAC rosette formation. The control group included 100 healthy persons, health service workers. Significantly higher incidence and levels were demonstrated of EA IC and EAC IC in the serum of patients in relation to the control group (p < 0.001). No correlation, however, was found between the appearance of EA IC and EAC IC and the degree of clinical progression of the disease, and the presence or absence of systemic symptoms. The presence of IC in the serum of patients with HD is one link in the whole chain of various immunological disturbances existing in this disease, the starting point of which can be a pathologically changed cell of the lymphatic system.
ISSN:0043-5147