Experimental study of a novel formulation for local application based on gentamicin, erythromycin and protease C

• Published in: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] Vol. 35; no. 9; p. 28
• Main Authors: Dolgova, G V, Berezhinskaia, V V, Egorenko, G G, Svinogeeva, T P, Shtegel'man, L A, Kagan, E Z, Nikitin, A V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.09.1990
• Subjects: Administration, Cutaneous; Animals; Drug Combinations; Drug Evaluation, Preclinical; Drug Therapy, Combination - administration & dosage; Drug Therapy, Combination - toxicity; Erythromycin - administration & dosage; Erythromycin - toxicity; Gentamicins - administration & dosage; Gentamicins - toxicity; Guinea Pigs; Ointments; Peptide Hydrolases - administration & dosage; Peptide Hydrolases - toxicity; Rats; Serine Endopeptidases; Wound Healing - drug effects
• ISSN: 0235-2990

A novel formulation for local application based on an enzyme of microbial origin, C protease, and two antibiotics, gentamicin and erythromycin, was studied on various experimental models in rats with respect to its effect on necrotic tissues and recovery of the skin and hypodermic tissue defects due to wounds. It was found that even within the first days of the application the formulation induced lysis of the primary crust, lowered exudation and promoted debridement, reduced the wound size and completely closed it. By its effect the formulation was similar to iruxol. In chronic experiments on animals with long-term application of the formulation to the skin and wound surfaces it showed no unfavourable general toxic or organotropic properties. The local irritating action was insignificant.