The correction of the functional activity of alveolar macrophages in inducing a primary immune response in influenza

• Published in: Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 4; p. 44
• Main Authors: Pozdeev, O K, Shulaeva, M P, Andreev, S V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.04.1992
• Subjects: Adjuvants, Immunologic - therapeutic use; Animals; Antigen-Presenting Cells - drug effects; Antigen-Presenting Cells - immunology; Antigens, Heterophile - immunology; Bronchoalveolar Lavage Fluid - cytology; Drug Combinations; Drug Evaluation, Preclinical; Immunity, Cellular - drug effects; Immunity, Cellular - immunology; Influenza A virus; Macrophages, Alveolar - drug effects; Macrophages, Alveolar - immunology; Mice; Mice, Inbred Strains; Orthomyxoviridae Infections - drug therapy; Orthomyxoviridae Infections - immunology; Sulfones - therapeutic use; Time Factors; Uracil - analogs & derivatives; Uracil - therapeutic use
• ISSN: 0372-9311; 2686-7613

The functional activity of alveolar macrophages obtained from mice, both healthy and infected with influenza virus A/Aichi 2/68 (H3N2), as manifested by their capacity to initiate the development of primary immune response to sheep red blood cells and Escherichia coli lipopolysaccharide after the transfer of these macrophages to intact syngeneic recipients was studied. The capacity of alveolar macrophages to perform antigen-presenting functions in the induction of humoral immune response was shown, and at the same time the development of experimental influenza infection was found to essentially decrease these properties. The injection of the immunomodulating agent diuciphon into experimental mice somewhat enhanced the immune response after the syngeneic transfer of alveolar macrophages from infected mice to intact recipients.