The role of dyslipoproteinemia in the genesis of chronic hepatitis

The dynamics of structural changes in the liver in experimental dyslipoproteinemia (DLP) and its correction was studied. Vessel-tissue changes found in the liver of rabbits in a short-term and stable DLP (4, 8 weeks) can be estimated as different stages of chronic active hepatitis. The microcirculat...

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Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 114; no. 10; p. 437
Main Authors Klimenko, E D, Pozdniakov, O M
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.10.1992
Subjects
Animals
Arteriosclerosis - complications
Arteriosclerosis - pathology
Cholesterol, Dietary - administration & dosage
Chronic Disease
Hepatitis, Animal - etiology
Hepatitis, Animal - pathology
Hyperlipoproteinemias - complications
Hyperlipoproteinemias - pathology
Liver - ultrastructure
Male
Microscopy, Electron
Rabbits
Remission, Spontaneous
Time Factors
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Summary:The dynamics of structural changes in the liver in experimental dyslipoproteinemia (DLP) and its correction was studied. Vessel-tissue changes found in the liver of rabbits in a short-term and stable DLP (4, 8 weeks) can be estimated as different stages of chronic active hepatitis. The microcirculation disorders and structural changes in the liver appeared at the early stages of DLP in the absence of atheromatosis in large arteries. The pathological changes in the liver existed 36 weeks after the rejection of atherogenic diet and correlated with DLP. Thus, DLP can be the risk factor as cardiovascular diseases as chronic nonspecific changes in the target organs.
ISSN:0365-9615