Effect of the immunostimulator tuftsin on the heart rate and body temperature of albino rats

Tetrapeptide tuftsin (0.3 mg/kg) affected the heart rate and body temperature depending on basal physiological parameters: when administered in the state of low heart rate tuftsin produced positive chronotropic effect, whereas at higher basal heart rate the bradycardiac response was observed. Tuftsi...

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Bibliographic Details
Published inFiziologicheskii zhurnal SSSR imeni I. M. Sechenova Vol. 74; no. 4; p. 547
Main Authors Kamenskiĭ, A A, Sarycheva, N Iu, Kalikhevich, V N
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.04.1988
Subjects
Animals
Body Temperature - drug effects
Drug Synergism
Heart Rate - drug effects
Male
Rats
Reserpine - pharmacology
Tuftsin - pharmacology
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Summary:Tetrapeptide tuftsin (0.3 mg/kg) affected the heart rate and body temperature depending on basal physiological parameters: when administered in the state of low heart rate tuftsin produced positive chronotropic effect, whereas at higher basal heart rate the bradycardiac response was observed. Tuftsin caused biphasic changes of the body temperature: transient hyperthermia in 5 min. after peptide injection with subsequent longer period of hypothermia followed by restoration of basal level. No effect of tuftsin occurred after reserpine injection. At the same time tuftsin potentiated the hypothermia induced by reserpine. The time course and sign of vegetative effects of tuftsin correlate with some of its behavioural effects.
ISSN:0015-329X