Effect of hormonally-induced prolongation of pregnancy in rabbits on maternal and fetal serum lipids

The alterations of the lipid metabolism produced by placental insufficiency were investigated in animal experiments. Pregnant rabbits received Chlormadinon-acetate by intramuscular injection. The pregnancy was prolongated for 4 days, and a placental insufficiency developed. The lipid metabolism of t...

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Bibliographic Details
Published inZentralblatt für Gynäkologie Vol. 107; no. 12; p. 744
Main Authors Ockert, C, Willgerodt, H, Keller, E, Senger, H, Pludra, R
Format Journal Article
LanguageGerman
Published Germany 1985
Subjects
Animals
Chlormadinone Acetate - pharmacology
Cholesterol - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Cholesterol, VLDL
Female
Gestational Age
Lipids - blood
Lipoproteins, LDL - blood
Lipoproteins, VLDL - blood
Maternal-Fetal Exchange - drug effects
Placenta Diseases - blood
Placental Insufficiency - blood
Pregnancy
Pregnancy, Prolonged
Rabbits
Triglycerides - blood
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Summary:The alterations of the lipid metabolism produced by placental insufficiency were investigated in animal experiments. Pregnant rabbits received Chlormadinon-acetate by intramuscular injection. The pregnancy was prolongated for 4 days, and a placental insufficiency developed. The lipid metabolism of the mothers and the fetuses was investigated by determination of beta-lipoproteides, triglycerides, cholesterol and HDL- and LDL/VLDL-cholesterol. The most important result is an increase of the concentrations of triglycerides and cholesterol of the fetuses during prolongation of pregnancy. Of the different cholesterol fractions estimated the LDL/VLDL-cholesterol-ratio excellently reflects the changes of the lipid metabolism during prolonged pregnancy.
ISSN:0044-4197