Paroxysmal nocturnal hemoglobinuria in pregnancy

The combination of paroxysmal nocturnal haemoglobinuria (PNH) and pregnancy occurred in three women aged 29, 31 and 35 years. One patient had a spontaneous abortion twice after which she committed suicide. In the other two the pregnancy and parturition--assisted--were without complications. However,...

Full description

Saved in:
Bibliographic Details
Published inNederlands tijdschrift voor geneeskunde Vol. 142; no. 42; p. 2308
Main Authors Lange, J G, Griever, G E, Brand, A, van Roosmalen, J
Format Journal Article
LanguageDutch
Published Netherlands 17.10.1998
Subjects
Abortion, Spontaneous
Adult
Female
Fetal Death
Hemoglobinuria, Paroxysmal - diagnosis
Hemoglobinuria, Paroxysmal - therapy
Humans
Prednisone - therapeutic use
Pregnancy
Pregnancy Complications, Hematologic
Pregnancy Outcome
Suicide
Thrombocytopenia - complications
Thrombosis - complications
Thrombosis - prevention & control
Treatment Outcome
Online AccessGet more information

Cover

More Information
Summary:The combination of paroxysmal nocturnal haemoglobinuria (PNH) and pregnancy occurred in three women aged 29, 31 and 35 years. One patient had a spontaneous abortion twice after which she committed suicide. In the other two the pregnancy and parturition--assisted--were without complications. However, one woman developed post-partum abdominal crises. The children were born at term and healthy. PNH is a rare form of haemolytic anemia. Pregnancy causes lethal complications in 6% of the cases of PNH, while 30% of the pregnancies end in spontaneous abortion or stillbirth. Accurate monitoring of pregnancy and the puerperium is essential.
ISSN:0028-2162