Importance of antiphosphatidylserine antibodies in patients with lupus anticoagulant. Analysis of 30 cases

Anti-phosphatidylserine (APS) and anticardiolipin (ACL) antibodies were measured in 30 patients with lupus anticoagulant. In 17 cases there were clinical features of thrombosis (56.7%). The number of patients with IgG APS and ACL levels higher than seven standard deviations from the normal mean was...

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Bibliographic Details
Published inMedicina clínica Vol. 95; no. 6; p. 210
Main Authors Zuazu-Jausoro, I, Oliver, A, Monserrat, I, Borrell, M, Garí, M, Pich, I, Grau, E, Fontcuberta, J
Format Journal Article
LanguageSpanish
Published Spain 07.07.1990
Subjects
Adult
Autoantibodies - blood
Blood Coagulation Factors - analysis
Blood Coagulation Factors - immunology
Cardiolipins - immunology
Female
Humans
Lupus Coagulation Inhibitor
Lupus Erythematosus, Systemic - immunology
Male
Middle Aged
Phosphatidylserines - immunology
Retrospective Studies
Thrombosis - immunology
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Summary:Anti-phosphatidylserine (APS) and anticardiolipin (ACL) antibodies were measured in 30 patients with lupus anticoagulant. In 17 cases there were clinical features of thrombosis (56.7%). The number of patients with IgG APS and ACL levels higher than seven standard deviations from the normal mean was significantly higher in the group with thrombosis (p less than 0.017 and p less than 0.02, respectively). The IgG APS level was higher in the group without systemic lupus erythematosus (p less than 0.029). There was a positive correlation between IgG APS and the activated thromboplastin time (r = 0.654, p less than 0.001). The correlation between IgG APS and IgG ACL was rho = 0.61. Two of the 5 patients with increased IgG APS and normal IgG ACL had thrombosis. We think that, in this group of patients, IgG APS titer may be, like IgG ACL, a biological marker of thrombosis risk.
ISSN:0025-7753