Significance of hereditary predisposition factors in the development and course of pulmonary tuberculosis

Comprehensive clinical, genetic, epidemiological, and immunogenetic studies have established that tuberculosis is a multifactorial disease whose development and natural history are due to the interaction of environmental factors, primarily, to infection and hereditary predisposition. Associations be...

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Bibliographic Details
Published inVestnik Rossiĭskoĭ akademii medits︠i︡nskih nauk no. 7; p. 6
Main Authors Chukanova, V P, Litvinov, V I, Pospelov, L E, Slogotskaia, L V
Format Journal Article
LanguageRussian
Published Russia (Federation) 1995
Subjects
Commonwealth of Independent States - epidemiology
Disease Susceptibility
HLA Antigens - genetics
HLA-DR2 Antigen - genetics
Humans
Prognosis
Tuberculosis, Pulmonary - epidemiology
Tuberculosis, Pulmonary - genetics
Tuberculosis, Pulmonary - immunology
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Summary:Comprehensive clinical, genetic, epidemiological, and immunogenetic studies have established that tuberculosis is a multifactorial disease whose development and natural history are due to the interaction of environmental factors, primarily, to infection and hereditary predisposition. Associations between tuberculosis and various HLA loci B antigens, as well as HLA locus D-DR2 antigen have been detected in different populations. The HLA genotype was shown to differ in patients with favourable and unfavourable tuberculosis natural history. The comprehensive study of genetic markers allows one to make a prompt assessment of the nature of a tuberculous process, to define its prognosis and to correct treatment.
ISSN:0869-6047