Preliminary evaluation of the effect of ibopamine on the secretion of prolactin

Ibopamine, diisobutyric ester of N-methyl dopamine, is an orally active dopaminergic agonist. The prolactin-lowering activity of Ibopamine was studied in 8 subjects with normal prolactine levels given the drug in a single dose of 100 mg. Prolactin levels measured by radioimmuno assay were evaluated...

Full description

Saved in:
Bibliographic Details
Published inBollettino della Societa italiana di biologia sperimentale Vol. 59; no. 11; p. 1631
Main Authors Scarazzati, E, Catenazzo, G, Melloni, C F, Ghirardi, P, Bianco, L
Format Journal Article
LanguageItalian
Published Italy 30.11.1983
Subjects
Adult
Aged
Deoxyepinephrine - analogs & derivatives
Deoxyepinephrine - pharmacology
Dopamine - analogs & derivatives
Female
Humans
Male
Middle Aged
Prolactin - blood
Time Factors
Online AccessGet more information

Cover

More Information
Summary:Ibopamine, diisobutyric ester of N-methyl dopamine, is an orally active dopaminergic agonist. The prolactin-lowering activity of Ibopamine was studied in 8 subjects with normal prolactine levels given the drug in a single dose of 100 mg. Prolactin levels measured by radioimmuno assay were evaluated before and within 2, 4 and 8 h of administration. Afterwards prolactin levels were evaluated after 4 and 8 days of treatment with Ibopamine administered at a dose of 50 mg three times daily. Ibopamine was shown to decrease prolactin to a statistically significant extent at the 2nd h after administration. At the 4th h prolactin returned to baseline values. After 4 and 8 treatment days prolactin levels did not differ significantly from baseline values. These results provide further evidence for the dopaminergic activity of Ibopamine and suggest a more through investigation in hyperprolactinemic subjects.
ISSN:0037-8771