Amoxicillin and clavulanic acid suspension for children in the treatment of bronchopulmonary infections

The present study has been tested on 30 children, 14 males and 16 females, average age 4.11 +/- 0.44 (range 9 months to 10 years), weight of 17.08 +/- 1.25 Kg, with infections concerning low respiratory tract (8 cases of broncho-pneumonia, 9 cases of acute bronchitis and 13 cases of lobar pneumonia)...

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Bibliographic Details
Published inLa Pediatria medica e chirurgica Vol. 11; no. 1; p. 65
Main Authors Pecco, P, Torta, L, Negro, F, Pavesio, D
Format Journal Article
LanguageItalian
Published Italy 01.01.1989
Subjects
Amoxicillin - therapeutic use
Amoxicillin-Potassium Clavulanate Combination
Child
Child, Preschool
Clavulanic Acids - therapeutic use
Drug Evaluation
Drug Therapy, Combination - therapeutic use
Female
Humans
Infant
Male
Respiratory Tract Infections - drug therapy
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Summary:The present study has been tested on 30 children, 14 males and 16 females, average age 4.11 +/- 0.44 (range 9 months to 10 years), weight of 17.08 +/- 1.25 Kg, with infections concerning low respiratory tract (8 cases of broncho-pneumonia, 9 cases of acute bronchitis and 13 cases of lobar pneumonia). It has been used a chemotherapy composed of amoxycillin and clavulanic acid in pediatric suspension of 312.5 mg/5 ml (in the ratio of 4 to 1); the daily dosage, related to the children's weight has been of 43.91 +/- 1.21 mg/Kg in two daily doses. On the average the therapy has lasted for 6.43 +/- 0.19 days from a minimum of 4 to a maximum of 8 days. During the treatment the symptomatologic parameters (dyspnoea, cough), and the objective ones (pathological lung signs, rales, hypophonesis, bronchial breath...) have progressively improved till they have disappeared; morning and evening body temperature has promptly returned to normal. Both the physical and radiological exams of the chest confirm either the improvement or the regression of the infection in most of the cases. Side effects due to the antibiotic have not been registered and local and general tolerability was excellent. Considering the more or less fast and complete symptomatological regression, the evolution of the infective clinical picture and the tolerability, the final evaluations have been: excellent efficacy in 13 cases, good efficacy in 9 cases, fairly good in 5 cases and poor in 3 cases.
ISSN:0391-5387