Effect of cerebral ischemia on synaptosomal uptake and release of 3H-5-hydroxytryptamine in adult and young Mongolian gerbils

Cerebral ischemia induced by bilateral common carotid artery occlusion (15 min) with and without release (1 hr) served as a model for comparative regional studies of synaptosomal 3H-5-hydroxytryptamine (3H-5-HT) uptake and release in adult and young gerbils. A decreased uptake and an increased relea...

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Bibliographic Details
Published inMetabolic brain disease Vol. 5; no. 1; p. 1
Main Authors Cvejic, V, Kumami, K, Spatz, M
Format Journal Article
LanguageEnglish
Published United States 01.03.1990
Subjects
Aging - metabolism
Animals
Gerbillinae
Ischemic Attack, Transient - metabolism
Serotonin - pharmacokinetics
Synaptosomes - metabolism
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Summary:Cerebral ischemia induced by bilateral common carotid artery occlusion (15 min) with and without release (1 hr) served as a model for comparative regional studies of synaptosomal 3H-5-hydroxytryptamine (3H-5-HT) uptake and release in adult and young gerbils. A decreased uptake and an increased release of 5-HT was observed in the adult after ischemia alone and/or ischemia with reflow. At the same time, 5-HT uptake was not affected except in the cortex and the release was reduced in the young. These findings indicate that the same ischemic insults affect differently the synaptosomal uptake and/or release of 5-HT in adult and young brain.
ISSN:0885-7490