Modulating effect of immunotherapy with modified tumor cells in transplantable lymphoma

Vibrio cholerici neuraminidase was studied on CBA mice for its effect on the strain NK/Ly lymphoid cells oncogenicity in intraabdominal transplantation. The 30% decrease in transplantability of cells treated by the enzyme in the dose of 50 U/ml was established. The modulating effect of specific acti...

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Bibliographic Details
Published inEksperimentalʹnaja onkologija Vol. 9; no. 2; p. 36
Main Authors Bratus', G G, Darchuk, G F, Komissarenko, V G, Nastenko, E P
Format Journal Article
LanguageRussian
Published Ukraine 1987
Subjects
Animals
Antibodies, Neoplasm - analysis
Cell Division
Female
Immunization
Leukocyte Count
Lymphoid Tissue - pathology
Lymphoma - immunology
Lymphoma - pathology
Lymphoma - therapy
Mice
Mice, Inbred CBA
Neoplasm Transplantation
Neuraminidase - immunology
Vibrio cholerae - enzymology
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Summary:Vibrio cholerici neuraminidase was studied on CBA mice for its effect on the strain NK/Ly lymphoid cells oncogenicity in intraabdominal transplantation. The 30% decrease in transplantability of cells treated by the enzyme in the dose of 50 U/ml was established. The modulating effect of specific active immunotherapy by modified cells in lymphoma was also studied. A pronounced stimulation of immunity T-cell links and proliferation in immunocompetent organs, an increase in the number of large granular lymphocytes in blood, specific antibody formation suppression were established. The problem of neuraminidase nonspecific effect on the tumour cells is under discussion.
ISSN:0204-3564