Liver transplantation in children: initial experience of the Instituto da Criança of the Hospital das Clínicas of Universidade de São Paulo

The initial experience at the Instituto da Criança do Hospital das Clínicas--School of Medicine of São Paulo University with liver transplantation in children is presented. A staff experienced in the management of children, including pediatric surgeons, hepatologists, critical care specialists, anes...

Full description

Saved in:
Bibliographic Details
Published inAMB : revista da Associacao Medica Brasileira Vol. 37; no. 4; p. 193
Main Authors Maksoud, J G, Chapchap, P, Porta, G, Miura, I, Carone Filho, E, Tannuri, U, da Silva, M M, Ayoub, A A, Santos, M M, Fauza, D de O
Format Journal Article
LanguagePortuguese
Published Brazil 01.10.1991
Subjects
Adolescent
Bacterial Infections - complications
Bacterial Infections - drug therapy
Brazil
Child
Child, Preschool
Cytomegalovirus Infections - complications
Cytomegalovirus Infections - drug therapy
Female
Humans
Immunosuppression
Length of Stay
Liver Diseases - complications
Liver Diseases - surgery
Liver Transplantation - mortality
Male
Postoperative Care
Survival Rate
Brazil
Online AccessGet more information

Cover

More Information
Summary:The initial experience at the Instituto da Criança do Hospital das Clínicas--School of Medicine of São Paulo University with liver transplantation in children is presented. A staff experienced in the management of children, including pediatric surgeons, hepatologists, critical care specialists, anesthesiologists, and other has been joined to draw therapeutic protocols. Afterward, more than 100 experimental liver transplant were performed in animals of medium size (dogs and pigs). From September, 1989 to July 1991, 12 liver transplants were performed on 9 children (3 retransplants) ranging in age from 2.5 to 17 years, being 5 boys and 4 girls. The donors had been selected according to the ABO blood group and body weight. Just once a blood A+ recipient received a liver from a blood O+ donor. The regular postoperative immunosuppression consisted of triple therapy with cyclosporin, prednisone and azathioprine. The postoperative stay in the Intensive Care Unit ranged from 3 to 24 days, according to the necessity of ventilatory support. These was no intraoperative mortality, arterial or venous thromboses, or early biliary complications. The overall survival is 78% (7/9). Primary non-function of the graft was the cause of death in two of our children. Although the number of cases is still small our results are comparable to those of the best liver transplant centers in the world.
ISSN:0102-843X