The antiproliferative activity of monoclonal anti-idiotypic antibodies imitating the biological effects of human alpha-interferons

The experimental data from the study of antiproliferative activity (AP-activity) of monoclonal antiidiotypic antibody (mono-Ai-At) imitating biological effects of human alpha interferons (h-IF-alpha) are presented. The mono-Ai-At present in the ascitic and culture fluids (the culture fluid was obtai...

Full description

Saved in:
Bibliographic Details
Published inVoprosy virusologiĭ Vol. 37; no. 1; p. 64
Main Authors Barkova, E P, Nagieva, F G, Andzhaparidze, O G
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.1992
Subjects
Animals
Antibodies, Anti-Idiotypic - isolation & purification
Antibodies, Monoclonal - isolation & purification
Cell Division - drug effects
Cell Line
Depression, Chemical
DNA - biosynthesis
DNA - drug effects
Humans
Hybrid Cells - cytology
Hybrid Cells - drug effects
Hybrid Cells - metabolism
Interferon-alpha - pharmacology
Time Factors
Online AccessGet more information

Cover

More Information
Summary:The experimental data from the study of antiproliferative activity (AP-activity) of monoclonal antiidiotypic antibody (mono-Ai-At) imitating biological effects of human alpha interferons (h-IF-alpha) are presented. The mono-Ai-At present in the ascitic and culture fluids (the culture fluid was obtained from cultivation of hybrid cells immobilized in alginate-gelatine gel) were shown to inhibit propagation of IF-sensitive continuous cells from normal and tumor tissues. The AP-activity of mono-Ai-At was found to be within the range of their antiviral activity. It is concluded that mono-Ai-At may be used as a new experimental model for investigation of h-IF-alpha biological effects.
ISSN:0507-4088