Propofol in single bolus for treatment of elevated intracranial hypertension

Eleven patients with intracranial pressure (ICP) above 20 mmHg despite hyperventilation and neurosedation were treated with a bolus of propofol (1.5 mg/kg) i.v. At baseline and 1-2-5-10-15-30-45 minutes after propofol administration we recorded the values of PIC, systolic arterial pressure (SAP) and...

Full description

Saved in:
Bibliographic Details
Published inMinerva anestesiologica Vol. 57; no. 6; p. 359
Main Authors Merlo, F, Demo, P, Lacquaniti, L, Tricarico, L, Faccin, G, Irone, M
Format Journal Article
LanguageItalian
Published Italy 01.06.1991
Subjects
Adolescent
Adult
Blood Pressure - drug effects
Brain Diseases - drug therapy
Brain Diseases - physiopathology
Cerebrovascular Circulation - drug effects
Female
Humans
Intracranial Pressure
Male
Middle Aged
Propofol - therapeutic use
Online AccessGet more information

Cover

More Information
Summary:Eleven patients with intracranial pressure (ICP) above 20 mmHg despite hyperventilation and neurosedation were treated with a bolus of propofol (1.5 mg/kg) i.v. At baseline and 1-2-5-10-15-30-45 minutes after propofol administration we recorded the values of PIC, systolic arterial pressure (SAP) and mean arterial pressure (MAP), heart rate (HR) and cerebral perfusion pressure (CPP), calculated as MAP less PIC. In the first ten minutes after propofol we observed a statistically significant (p less than 0.05) decrease of ICP and SAP. MAP decreased in the first five minutes only. Consequently HR increased at the same time. CPP decreased in the first two minutes after administration of the drug, but without statistical evidence. We conclude that propofol, in our opinion, can be used to treat intracranial hypertension but the hemodynamic effects in hypovolemic patients must be taken into consideration.
ISSN:0375-9393