Deep venous thrombosis and neoplastic pathology: our experience in emergencies

Deep vein thrombosis incidence is 1/1000 per year; it is associated with many risk factors which is considered as "thrombophilic states". Its pathogenesis is complex, caused by alterations of hemostasis system. Many studies have established the relation between cancer and subsequent venous...

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Published inIl Giornale di chirurgia Vol. 19; no. 6-7; p. 293
Main Authors Schillaci, F, Stagnitti, F, Iurato, C, Mongardini, M, Dall'olio, D, Salvi, P F, Cazzaniga, M, Bresadola, L, Schultze, W, Natalini, E
Format Journal Article
LanguageItalian
Published Italy 01.06.1998
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
Breast Neoplasms - complications
Colonic Neoplasms - complications
Emergencies
Female
Humans
Male
Middle Aged
Neoplasms - complications
Polyps - complications
Pulmonary Embolism - prevention & control
Rectal Neoplasms - complications
Retrospective Studies
Risk Factors
Stomach Neoplasms - complications
Thrombophlebitis - complications
Thrombophlebitis - etiology
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Summary:Deep vein thrombosis incidence is 1/1000 per year; it is associated with many risk factors which is considered as "thrombophilic states". Its pathogenesis is complex, caused by alterations of hemostasis system. Many studies have established the relation between cancer and subsequent venous thromboembolism, confirming the relationship of neoplastic cell interaction with coagulation system. Forty-seven patients admitted to the hospital from 1987 to 1996 with symptomatic clinically proved deep vein thrombosis were included in a retrospective study. Routine examination at the time of diagnosis of deep vein thrombosis revealed an occult cancer in 8 out of 47 patients; 9 out of 47 patients were admitted in hospital with vein thrombosis and known cancer. The aim of this study is to suggest the best, first treatment of vein thromboembolism in emergency to avoid the dangerous pulmonary embolism complication. The patients affected with deep vein thrombosis and cancer were elderly (over 70 years old, in mean); the neoplasia was of digestive system (8/17) in advanced metastatic stage there was cancer familiarity in 7 out of 47 patients. The high risk of pulmonary embolism associated to deep vein thrombosis suggests the importance of early starting the anticoagulant therapy and placing caval filter.
ISSN:0391-9005