Functional interrelations of monoamines, thyrotropic hormone and thyroid hormones in hyperprolactinemia

Functional interrelationships of serotonin, dopamine, prolactin, TRH and thyroid hormones in patients with hyperprolactinemia were studied. Altogether 26 patients with amenorrhea in hyperprolactinemia without clinical signs of disorder of thyroid function were examined. The levels of serotonin and d...

Full description

Saved in:
Bibliographic Details
Published inProblemy ėndokrinologii Vol. 33; no. 4; p. 27
Main Authors Shikaeva, F V, Koreneva, G P
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.1987
Subjects
Adult
Dopamine - physiology
Female
Homeostasis
Humans
Hyperprolactinemia - physiopathology
Neurotransmitter Agents - physiology
Serotonin - physiology
Thyroid Hormones - physiology
Thyrotropin - physiology
Online AccessGet more information

Cover

More Information
Summary:Functional interrelationships of serotonin, dopamine, prolactin, TRH and thyroid hormones in patients with hyperprolactinemia were studied. Altogether 26 patients with amenorrhea in hyperprolactinemia without clinical signs of disorder of thyroid function were examined. The levels of serotonin and dopamine were determined by spectrofluorimetry, the level of hormones was determined by a radioimmunoassay. An increase in the level of serotonin and a decrease in the level of dopamine in all the patients, a decrease in TRH and T4, and an increase in T3 were noted. The levels of monoamines, TRH and thyroid hormones showed correlation. It has been concluded that disorder of the monoaminergic mechanisms of regulation creates conditions for the rearrangement of hormonal interrelationships in the neuroendocrine functional system and determines the involvement of the hypophyseothyroid system in the pathological process. Therefore patients with hyperprolactinemia are at risk of developing thyroid functional disorders.
ISSN:0375-9660