Mechanism of the inhibition of proliferation of hapten-modified human and mouse leukemic cells by hapten-specific T-suppressor factor

T-suppressor-inducer and T-suppressor-effector hybridoma supernatants both regulating the DTH reaction intensity triggered by trinitrophenyl-sulphonic acid (TNPSA) or antigen-dependent proliferation of mice lymph node cells to trinitrophenylated bovine serum albumin, possess and ability to inhibit p...

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Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 108; no. 7; p. 67
Main Authors Chernousov, A D, Medunitsyn, N V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.1989
Subjects
Animals
Cell Division
Cell Line
Cyclic AMP - analysis
Haptens
Humans
Hybridomas
Leukemia - immunology
Leukemia - pathology
Leukemia, Experimental - immunology
Leukemia, Experimental - pathology
Mice
T-Lymphocytes, Regulatory - immunology
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Summary:T-suppressor-inducer and T-suppressor-effector hybridoma supernatants both regulating the DTH reaction intensity triggered by trinitrophenyl-sulphonic acid (TNPSA) or antigen-dependent proliferation of mice lymph node cells to trinitrophenylated bovine serum albumin, possess and ability to inhibit proliferation of TNPSA-modified human and mice leukaemic cells. This effect is specific, and is caused from antigen binding. This effect is specific, and is caused from antigen binding, idiotype positive T-suppressor factors and is based on a cyclic adenosine monophosphate increase of the concentration in target cells.
ISSN:0365-9615