Amplification of nucleotide sequences homologous to the viral myc oncogene in DNA of colonic mucosa in a patient with cancer of the same location

Genomic DNA of intact colonic mucosa obtained from a female patient suffering colonic cancer revealed amplified nucleotide sequences (multiple copies) related to viral myc oncogene. The study failed to detect amplification in tumor. Causation and pathways of the event are discussed.

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Bibliographic Details
Published inVoprosy onkologij Vol. 31; no. 8; p. 52
Main Authors Seĭts, I F, Fedorov, S N, Serova, O M, Kalinovskiĭ, V P, Kniazev, P G
Format Journal Article
LanguageRussian
Published Russia (Federation) 1985
Subjects
Base Sequence
Colon - ultrastructure
Colonic Neoplasms - genetics
DNA, Neoplasm - genetics
Female
Gene Amplification
Humans
Intestinal Mucosa - ultrastructure
Oncogenes
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Summary:Genomic DNA of intact colonic mucosa obtained from a female patient suffering colonic cancer revealed amplified nucleotide sequences (multiple copies) related to viral myc oncogene. The study failed to detect amplification in tumor. Causation and pathways of the event are discussed.
ISSN:0507-3758