An increased frequency of allele A6 of the proto-oncogene HRAS1 in cancer patients

Size and frequency of rare alleles of HRAS1 protooncogene were studied in 258 patients with various neoplasms and 32 healthy donors of the northwestern region of the USSR. Literature data on distribution of rare alleles of certain size in sick and healthy people were compared to our results. On the...

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Bibliographic Details
Published inVoprosy onkologij Vol. 37; no. 6; p. 700
Main Authors Nikiforova, I F, Pluzhnikova, G F, Serova, O M, Kniazev, P G
Format Journal Article
LanguageRussian
Published Russia (Federation) 1991
Subjects
Alleles
DNA, Neoplasm - genetics
Female
Gene Frequency
Genotype
Humans
Neoplasms - genetics
Proto-Oncogenes - genetics
Restriction Mapping
USSR
USSR
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Summary:Size and frequency of rare alleles of HRAS1 protooncogene were studied in 258 patients with various neoplasms and 32 healthy donors of the northwestern region of the USSR. Literature data on distribution of rare alleles of certain size in sick and healthy people were compared to our results. On the whole, 1918 HRAS1 alleles from cancer patients and 1104 alleles from donors were considered. The study established a significant increase in the frequency of rare A6 allele in cancer patients.
ISSN:0507-3758