Infusion of phenytoin concentrate in a child (author's transl)

In a four-year-old boy receiving phenytoin for seizures, the phenytoin blood level after 1000 mg phenytoin given over 24 hours alternatively intravenously (600 mg) and intramuscularly (400 mg) was found to be 14.7 mu g/ml. After 12 hours of intravenous infusion of 750 mg phenytoin concentrate the co...

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Bibliographic Details
Published inDeutsche medizinische Wochenschrift Vol. 100; no. 18; p. 1012
Main Authors Oelkers, W, Schäfer, H, Reith, H
Format Journal Article
LanguageGerman
Published Germany 02.05.1975
Subjects
Age Factors
Child, Preschool
Humans
Injections, Intramuscular
Injections, Intravenous
Male
Phenytoin - administration & dosage
Phenytoin - blood
Time Factors
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Summary:In a four-year-old boy receiving phenytoin for seizures, the phenytoin blood level after 1000 mg phenytoin given over 24 hours alternatively intravenously (600 mg) and intramuscularly (400 mg) was found to be 14.7 mu g/ml. After 12 hours of intravenous infusion of 750 mg phenytoin concentrate the concentration was 18.7 mug/ml. When 750 mg phenytoin were given over more than 18 hours the phenytoin blood level was only 7.4 mug/ml.
ISSN:0012-0472