Fatal toxic hepatitis associated with administration of dantrolene (author's transl)

A 50 year-old female diabetic patient with disseminated sclerosis presented fatal cholestatic hepatitis about ten weeks after the initiation of dantrolene therapy (600 mg/day). Clinical findings, biochemical results and the appearance of hepatic biopsy are described and compared with other cases rep...

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Bibliographic Details
Published inActa neurologica Belgica Vol. 80; no. 6; p. 336
Main Authors Cornette, M, Gillard, C, Borlee-Hermans, G
Format Journal Article
LanguageFrench
Published Italy 1980
Subjects
Chemical and Drug Induced Liver Injury - etiology
Chemical and Drug Induced Liver Injury - pathology
Cholestasis - complications
Dantrolene - adverse effects
Diabetes Complications
Female
Humans
Liver - pathology
Middle Aged
Multiple Sclerosis - complications
Multiple Sclerosis - drug therapy
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Summary:A 50 year-old female diabetic patient with disseminated sclerosis presented fatal cholestatic hepatitis about ten weeks after the initiation of dantrolene therapy (600 mg/day). Clinical findings, biochemical results and the appearance of hepatic biopsy are described and compared with other cases reported to date. Hypotheses regarding the hepatotoxicity of dantrolene and essential precautions to be taken when using this medication are deduced.
ISSN:0300-9009